Phenotypes associated with this allele

• Allele Symbol: Tia1^tm1Andp
• Allele Name: targeted mutation 1, Paul Anderson
• Allele ID: MGI:3037091
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tia1^tm1Andp/Tia1^tm1Andp	B6.Cg-Tia1^tm1Andp	MGI:3037331
hm2	Tia1^tm1Andp/Tia1^tm1Andp	C.129S2-Tia1^tm1Andp	MGI:3037319
cx3	Tia1^tm1Andp/Tia1^tm1Andp Zfp36^tm1Pjb/Zfp36^tm1Pjb	B6.Cg-Tia1^tm1Andp Zfp36^tm1Pjb	MGI:3037328

Genotype
MGI:3037331

hm1

• Allelic Composition: Tia1^tm1Andp/Tia1^tm1Andp
• Genetic Background: B6.Cg-Tia1^tm1Andp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

autoimmune arthritis ( J:88443 )

• homozygotes develop mild arthritis

• swollen joints display minimal display inflammatory pannus and rare bony erosions

skeleton

autoimmune arthritis ( J:88443 )

• homozygotes develop mild arthritis

• swollen joints display minimal display inflammatory pannus and rare bony erosions

Genotype
MGI:3037319

hm2

• Allelic Composition: Tia1^tm1Andp/Tia1^tm1Andp
• Genetic Background: C.129S2-Tia1^tm1Andp

mortality/aging

postnatal lethality, incomplete penetrance ( J:88770 )

• approximately 50% of homozygotes die between E16.5 and 3 weeks

• survivors appear normal and live up to 2 years

hematopoietic system

hematopoietic system phenotype ( J:88770 )

N • major hematopoietic lineages are in normal proportions

abnormal macrophage physiology ( J:88770 )

• in macrophages from homozygotes lipopolysaccharide-induced expression of TNF- alpha and IL-6 is significantly increased

immune system

immune system phenotype ( J:88770 )

N • the thymus is normal

abnormal macrophage physiology ( J:88770 )

• in macrophages from homozygotes lipopolysaccharide-induced expression of TNF- alpha and IL-6 is significantly increased

increased susceptibility to endotoxin shock ( J:88770 )

• mutants are more susceptible to lipopolysaccharide-induced endotoxin shock

Genotype
MGI:3037328

cx3

• Allelic Composition: Tia1^tm1Andp/Tia1^tm1Andp; Zfp36^tm1Pjb/Zfp36^tm1Pjb
• Genetic Background: B6.Cg-Tia1^tm1Andp Zfp36^tm1Pjb

growth/size/body

postnatal growth retardation ( J:88443 )

• double homozygotes are small at birth and grow slowly

skeleton

increased synovial pannus formation ( J:88443 )

• in finger joints

autoimmune arthritis ( J:88443 )

• double homozygotes develop arthritis that is more severe than that seen in either single homozygote

• finger joints from double homozygotes display inflammatory pannus and bony erosions

immune system

increased neutrophil cell number ( J:88443 )

• significant increases in neutrophils are found in the bone marrow and peripheral blood

abnormal macrophage physiology ( J:88443 )

• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased

increased synovial pannus formation ( J:88443 )

• in finger joints

autoimmune arthritis ( J:88443 )

• double homozygotes develop arthritis that is more severe than that seen in either single homozygote

• finger joints from double homozygotes display inflammatory pannus and bony erosions

hematopoietic system

increased neutrophil cell number ( J:88443 )

• significant increases in neutrophils are found in the bone marrow and peripheral blood

abnormal macrophage physiology ( J:88443 )

• in macrophages from double homozygotes lipopolysaccharide-induced expression of TNF- alpha is significantly increased