Phenotypes associated with this allele
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: 129S1/Sv * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• Background Sensitivity: only 8.2% of mice survive until 4 weeks on a 129S1, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: A/J * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• Background Sensitivity: only 5.8% of mice survive until 4 weeks on a A/J, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: BALB/cByJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• only 7.4% of mice survive until 4 weeks on a BALB/cByJ, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: C3H/HeJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• Background Sensitivity: only 2.2% of mice survive until 4 weeks on a C3H/HeJ, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• Background Sensitivity: only 1.1% of mice survive until 4 weeks on a C57BL/6 background
|
|
|
• most mice die within the first day of birth
|
behavior/neurological
|
|
• mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures
|
growth/size/body
|
|
• mice that survive for more than 6 months are smaller in size compared to wild-type mice
|
nervous system
|
|
• mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: C57BL/6J * EL/EFrkJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• only 3.6% of mice survive until 4 weeks on a EL/EFrkJ, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4Ff
|
|
Genetic
Background |
involves: C57BL/6J * FVB/NJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
mortality/aging
|
|
• only 5.6% of mice survive until 4 weeks on a FVB/NJ, C57BL/6 mixed background
|
behavior/neurological
|
|
• Background Sensitivity: mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background
|
nervous system
|
|
• Background Sensitivity: mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background
|
Allelic
Composition |
Celf4Ff/Celf4+
|
|
Genetic
Background |
involves: C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celf4Ff mutation
(1 available);
any
Celf4 mutation
(27 available)
|
|
|
Celf4Ff/Brunol4+ mice exhibit seizures
behavior/neurological
|
|
• mice are slightly hyperactive
|
|
|
• at 3 months of age, mice exhibit seizures
• seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
• seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
• incidence of seizures decrease with age
|
|
|
• at 7 weeks, mice have a reduce threshold to electroconvulsive seizure
|
growth/size/body
|
|
• by week 35 mice are 10% heavier than wild-type mice
|
|
|
• mice exhibit a late-onset weight gain resulting in 10% heavier weight compared to wild-type mice
|
|
|
• mice are slightly smaller at weaning
|
nervous system
|
|
• at 3 months of age, mice exhibit seizures
• seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
• seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
• incidence of seizures decrease with age
|
|
|
• at 7 weeks, mice have a reduce threshold to electroconvulsive seizure
|
Analysis Tools
