Phenotypes associated with this allele
Allelic
Composition |
Elk4tm1Rtr/Elk4tm1Rtr
|
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Genetic
Background |
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
|
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|
hematopoietic system
|
|
• abnormal thymocyte selection and/or differentiation
|
|
|
• T cell autonomous defect affecting positive, but not negative, selection
|
|
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• reduced number of peripheral T cells
|
|
|
• 50% reduction in the proportion of TCRhi thymocytes
|
|
|
• 50% reduction in the proportion of single-positive CD4+thymocytes
|
|
|
• reduction in the proportion of single-positive CD8+ thymocytes
|
immune system
|
|
• abnormal thymocyte selection and/or differentiation
|
|
|
• T cell autonomous defect affecting positive, but not negative, selection
|
|
|
• reduced number of peripheral T cells
|
|
|
• 50% reduction in the proportion of TCRhi thymocytes
|
|
|
• 50% reduction in the proportion of single-positive CD4+thymocytes
|
|
|
• reduction in the proportion of single-positive CD8+ thymocytes
|
endocrine/exocrine glands
|
|
• 50% reduction in the proportion of TCRhi thymocytes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1tm1Nor mutation
(0 available);
any
Elk1 mutation
(8 available)
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
|
|
|
vision/eye
|
N |
• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls
• no retinal neovascularization is observed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1tm1Nor mutation
(0 available);
any
Elk1 mutation
(8 available)
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
|
|
|
vision/eye
|
N |
• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls
• no retinal neovascularization is observed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
|
|
|
hematopoietic system
|
|
• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
|
|
|
• mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
|
|
|
• decrease in splenic CD4:CD8 ratio
|
immune system
|
|
• CD4 thymocyte positive selection is impaired; mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
|
|
|
• mutants generate about 75% fewer CD4+ single-positive thymocytes than wild-type
|
|
|
• decrease in splenic CD4:CD8 ratio
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
Tg(TcrLCMV)327Sdz mutation
(8 available)
|
|
|
hematopoietic system
|
|
• CD8 thymocyte positive selection is impaired: the proportion of CD8+ single positive thymocytes is reduced by about 75% and gating on TCRhi cells show almost 90% reduction
|
|
|
• the proportion of CD8+ single positive thymocytes is reduced by about 75% and gating on TCRhi cells show almost 90% reduction
|
immune system
|
|
• CD8 thymocyte positive selection is impaired: the proportion of CD8+ single positive thymocytes is reduced by about 75% and gating on TCRhi cells show almost 90% reduction
|
|
|
• the proportion of CD8+ single positive thymocytes is reduced by about 75% and gating on TCRhi cells show almost 90% reduction
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk4tm1Rtr mutation
(0 available);
any
Elk4 mutation
(17 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation
(3 available)
|
|
|
hematopoietic system
|
|
• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8+ single-positive thymocyte numbers and 60% reduction in the proportion of TCRhi cells
|
|
|
• females show an approximate 80% reduction in CD8+ single-positive thymocyte numbers and 60% reduction in the proportion of TCRhi cells
|
immune system
|
|
• CD8 thymocyte positive selection is impaired; females show an approximate 80% reduction in CD8+ single-positive thymocyte numbers and 60% reduction in the proportion of TCRhi cells
|
|
|
• females show an approximate 80% reduction in CD8+ single-positive thymocyte numbers and 60% reduction in the proportion of TCRhi cells
|
Analysis Tools