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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Kit-cre)143Hmb
transgene insertion 143, Dan Holmberg
MGI:3036304
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tcf4tm1Hmb/Tcf4tm1Zhu
Tg(Kit-cre)143Hmb/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3719236


Genotype
MGI:3719236
cn1
Allelic
Composition		 Tcf4tm1Hmb/Tcf4tm1Zhu
Tg(Kit-cre)143Hmb/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf4tm1Hmb mutation (0 available); any Tcf4 mutation (63 available)
Tcf4tm1Zhu mutation (1 available); any Tcf4 mutation (63 available)
Tg(Kit-cre)143Hmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected
abnormal B cell differentiation ( J:65236 )
• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
decreased double-positive T cell number ( J:65236 )
• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
spleen hypoplasia ( J:65236 )
• fewer splenocytes with the Tcf4tm1Hmb allele are detected

immune system
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected
abnormal B cell differentiation ( J:65236 )
• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
decreased double-positive T cell number ( J:65236 )
• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
spleen hypoplasia ( J:65236 )
• fewer splenocytes with the Tcf4tm1Hmb allele are detected

endocrine/exocrine glands
decreased thymocyte number ( J:65236 )
• fewer thymocytes with the Tcf4tm1Hmb allele are detected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory