Phenotypes associated with this allele

• Allele Symbol: Tg(Kit-cre)143Hmb
• Allele Name: transgene insertion 143, Dan Holmberg
• Allele ID: MGI:3036304
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tcf4^tm1Hmb/Tcf4^tm1Zhu Tg(Kit-cre)143Hmb/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3719236

Genotype
MGI:3719236

cn1

• Allelic Composition: Tcf4^tm1Hmb/Tcf4^tm1Zhu; Tg(Kit-cre)143Hmb/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

immune system

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected

abnormal B cell differentiation ( J:65236 )

• fewer B220-CD3- B cells with the Tcf4^tm1Hmb allele are detected

decreased double-positive T cell number ( J:65236 )

• fewer immature CD4+CD8+ T cells with the Tcf4^tm1Hmb allele are detected

spleen hypoplasia ( J:65236 )

• fewer splenocytes with the Tcf4^tm1Hmb allele are detected

endocrine/exocrine glands

decreased thymocyte number ( J:65236 )

• fewer thymocytes with the Tcf4^tm1Hmb allele are detected