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Allele Symbol Allele Name Allele ID |
Il23atm1Ngh targeted mutation 1, Nico Ghilardi MGI:3036163 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• died from around day 10 to day 14 after inoculation with C. rodentium
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• died from around day 10 to day 14 after inoculation with C. rodentium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
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• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
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• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
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• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
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• low levels of IL22 after DSS treatment
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• increase in levels after DSS treatment is less than for controls
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• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
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• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type mice
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• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
|
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• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
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• low levels of IL22 after DSS treatment
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• increase in levels after DSS treatment is less than for controls
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• significantly less weight loss after treatment with Sodium Dextran Sulfate (DSS) than in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a slight but significant skewing of cell populations toward CD8+ phenotype
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• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
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• OVA specific IgA levels were reduced relative to controls after primary immunization
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• OVA specific IgG2a levels were reduced relative to controls after primary immunization
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• inefficient responses by CD4+ T cells
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• defect in memory T cell activation
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• a slight but significant skewing of cell populations toward CD8+ phenotype
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• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
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• OVA specific IgA levels were reduced relative to controls after primary immunization
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• OVA specific IgG2a levels were reduced relative to controls after primary immunization
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• inefficient responses by CD4+ T cells
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• defect in memory T cell activation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced colorectal tumor multiplicity and grown due to reduced cell proliferation compared with Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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