Analysis Tools|
Allele Symbol Allele Name Allele ID |
Il23atm1Ngh targeted mutation 1, Nico Ghilardi MGI:3036163 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• died from around day 10 to day 14 after inoculation with C. rodentium
|
|
• died from around day 10 to day 14 after inoculation with C. rodentium
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
|
|
• less colon shortening
• decreased leukocyte infiltration
• less crypt loss
• reduced epithelial hyperplasia
|
|
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
|
|
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
|
|
• low levels of IL22 after DSS treatment
|
|
• increase in levels after DSS treatment is less than for controls
|
|
• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
|
|
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
• 15 days after aerosol challenge with M. tuberculosis, mice fail to produce mononuclear granulomatous structures as wild-type mice do
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type mice
|
|
• 15 days after aerosol challenge with M. tuberculosis, mice produce less CD4+ T cells with an activated CD44hiCXCR3+ phenotype than wild-type
|
|
• following vaccination against M. tuberculosis, mice do not lower bacterial burden in the lung 30 days after challenge and fail to elicit an accelerated IFN-gamma or IL-17 T cell recall response
|
|
• low levels of IL22 after DSS treatment
|
|
• increase in levels after DSS treatment is less than for controls
|
|
• significantly less weight loss after treatment with Sodium Dextran Sulfate (DSS) than in controls
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• a slight but significant skewing of cell populations toward CD8+ phenotype
|
|
• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
|
|
• OVA specific IgA levels were reduced relative to controls after primary immunization
|
|
• OVA specific IgG2a levels were reduced relative to controls after primary immunization
|
|
• inefficient responses by CD4+ T cells
|
|
• defect in memory T cell activation
|
|
• a slight but significant skewing of cell populations toward CD8+ phenotype
|
|
• after a second immunization, all OVA specific Ig isotypes were reduced relative to controls
|
|
• OVA specific IgA levels were reduced relative to controls after primary immunization
|
|
• OVA specific IgG2a levels were reduced relative to controls after primary immunization
|
|
• inefficient responses by CD4+ T cells
|
|
• defect in memory T cell activation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• reduced colorectal tumor multiplicity and grown due to reduced cell proliferation compared with Apctm1Tno/Apc+ Tg(CDX2-cre)101Erf mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
