Phenotypes associated with this allele

• Allele Symbol: Lmo4^tm2Sho
• Allele Name: targeted mutation 2, Stuart Orkin
• Allele ID: MGI:3035914
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmo4^tm2Sho/Lmo4^tm2Sho	either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)	MGI:3035942

Genotype
MGI:3035942

hm1

• Allelic Composition: Lmo4^tm2Sho/Lmo4^tm2Sho
• Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88168 )

• although homozygotes are born in the expected Mendelian ratio, all died within the first day

craniofacial

abnormal sphenoid bone morphology ( J:88168 )

• in about 50% of homozygotes

• trabecula basal plate largely missing

• inferior half of optic canal poorly formed

absent presphenoid bone ( J:88168 )

• presphenoid absent or lacking lateral processes

skeleton

abnormal sphenoid bone morphology ( J:88168 )

• in about 50% of homozygotes

• trabecula basal plate largely missing

• inferior half of optic canal poorly formed

absent presphenoid bone ( J:88168 )

• presphenoid absent or lacking lateral processes

abnormal sternocostal joint morphology ( J:88168 )

• occasional failure of the first rib to attach to sternum

• 8th rib frequently attaches to sternum

cervical vertebral fusion ( J:88168 )

• abnormalities seen in cervical vertebrae including fusion of C2 and C3

nervous system

open neural tube ( J:88168 )

• failed to close in the mid and hindbrain regions

exencephaly ( J:88168 )

• in about 50% of homozygotes on a CD1 background

• less than 10% of homozygotes on a C567BL/6 background

abnormal cranial nerve morphology ( J:88168 )

fusion of glossopharyngeal and vagus nerve ( J:88168 )

• occurs in about 50% of homozygotes

abnormal trigeminal nerve morphology ( J:88168 )

• branch to 2nd branchial arch is missing

embryo

open neural tube ( J:88168 )

• failed to close in the mid and hindbrain regions

growth/size/body

absent presphenoid bone ( J:88168 )

• presphenoid absent or lacking lateral processes