Phenotypes associated with this allele

• Allele Symbol: Lmo4^tm2Thr
• Allele Name: targeted mutation 2, Terence H Rabbitts
• Allele ID: MGI:3035827
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lmo4^tm1Thr/Lmo4^tm2Thr	involves: 129S/SvEv * C57BL/6	MGI:3035885

Genotype
MGI:3035885

ht1

• Allelic Composition: Lmo4^tm1Thr/Lmo4^tm2Thr
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:88167 )

• approximately 50% of homozygotes die during late gestation

neonatal lethality, incomplete penetrance ( J:88167 )

• the remaining 50% die at birth

respiratory system

abnormal nose morphology ( J:88167 )

• at E18.5, the nasal part of the face is more broad and protruded than in wild-type and heterozygous littermates

craniofacial

acrania ( J:88167 )

• absence of the cranium

abnormal nose morphology ( J:88167 )

• at E18.5, the nasal part of the face is more broad and protruded than in wild-type and heterozygous littermates

embryo

decreased embryo size ( J:88167 )

abnormal neural tube morphology ( J:88167 )

growth/size/body

abnormal nose morphology ( J:88167 )

• at E18.5, the nasal part of the face is more broad and protruded than in wild-type and heterozygous littermates

decreased embryo size ( J:88167 )

hematopoietic system

hematopoietic system phenotype ( J:88167 )

N • normal hematopoiesis

skeleton

acrania ( J:88167 )

• absence of the cranium

nervous system

abnormal neural tube morphology ( J:88167 )

abnormal brain development ( J:88167 )

abnormal cerebral cortex morphology ( J:88167 )

• disrupted architecture due to widespread necrosis

anencephaly ( J:88167 )

• incomplete penetrance

• approximately one-third of fetuses completely lacked a cranium and featured a severely malformed brain

exencephaly ( J:88167 )

• exhibited by approximately 50% of mice

integument

pallor ( J:88167 )