Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Miv mutation
(0 available);
any
Hsf1 mutation
(25 available)
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cellular
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• increased sensitivity to heat stress was seen in bone marrow cells and fibroblasts
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• mouse embryo fibroblasts have an increased sensitivity to many apoptosis inducing agents
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reproductive system
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• although homozygous females are infertile, homozygous males are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hsf1tm1Miv mutation
(0 available);
any
Hsf1 mutation
(25 available)
Hsf2tm1Miv mutation
(0 available);
any
Hsf2 mutation
(37 available)
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Testes are smaller in Hsf2tm1Miv/Hsf2tm1Miv and Hsf1tm1Miv/Hsf1tm1Miv Hsf2tm1Miv/Hsf2tm1Miv mice
cellular
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• total lack of sperm in seminal fluid
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mortality/aging
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• reduced numbers of double homozygotes are born
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endocrine/exocrine glands
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• large vacuolated structures and large multinucleated giant cells found in tubules
• large numbers of apoptotic cells in tubules of testes
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• less than 50% of wild-type
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growth/size/body
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• reduced by about 20% compared to wild-type
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• reduced by about 20% compared to wild-type
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reproductive system
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• large vacuolated structures and large multinucleated giant cells found in tubules
• large numbers of apoptotic cells in tubules of testes
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• less than 50% of wild-type
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• total lack of sperm in seminal fluid
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• the most advanced germ cells present are spermatogonia and pachytene spermatocytes indicating male meiosis does not progress beyond prophase I
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Analysis Tools