About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
GckRgsc475
RIKEN Genomic Sciences Center (GSC), 475
MGI:3033226
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
GckRgsc475/Gck+ involves: C57BL/6J * DBA/2J MGI:3038220


Genotype
MGI:3038220
ht1
Allelic
Composition
GckRgsc475/Gck+
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GckRgsc475 mutation (1 available); any Gck mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose
• mutants have a free fed serum glucose level of 200 mg/dl or more, this was the basis for selection in the ENU screen
• mutants have impaired glucose responsive insulin secretion
• during an oral glucose tolerance test blood glucose levels are significantly higher

hematopoietic system
• increased glycosylated hemoglobin indicating a prolonged increase in serum glucose

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
maturity-onset diabetes of the young type 2 DOID:0111100 OMIM:125851
J:88919





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/16/2024
MGI 6.23
The Jackson Laboratory