Phenotypes associated with this allele

• Allele Symbol: Tg(Lck*F505)2964Rmp
• Allele Name: transgene insertion 2964, Roger M Perlmutter
• Allele ID: MGI:3032774
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ptprc^tm1Holm/Ptprc^tm1Holm Tg(Lck*F505)2964Rmp/?	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3032909
tg2	Tg(Lck*F505)2964Rmp/?	involves: C57BL/6J * DBA/2	MGI:3032812

Genotype
MGI:3032909

cx1

• Allelic Composition: Ptprc^tm1Holm/Ptprc^tm1Holm; Tg(Lck*F505)2964Rmp/?
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• extensive metastasis

• earliest morbidity at 5 weeks and median survival was to 9.5 weeks

• thymomas originate from immature thymocytes

immune system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

hematopoietic system

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

endocrine/exocrine glands

thymus hyperplasia ( J:64671 )

• thymus glands with tumours also have 5X normal cell numbers

increased T cell derived lymphoma incidence ( J:64671 )

• aggressive thymic tumors in 100% of mice

• extensive metastasis

• earliest morbidity at 5 weeks and median survival was to 9.5 weeks

• thymomas originate from immature thymocytes

Genotype
MGI:3032812

tg2

• Allelic Composition: Tg(Lck*F505)2964Rmp/?
• Genetic Background: involves: C57BL/6J * DBA/2

neoplasm

neoplasm ( J:88309 )

N • unlike mice carrying transgenes of this gene which express greater than 20 pg of mRNA per ug of total RNA, no thymic tumors develop during the first year of life