Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gli2tm5.1(GLI3)Alj targeted mutation 5.1, Alexandra L Joyner MGI:3032719 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• pups live for only 2 days after birth
|
|
• abnormal spatial patterning of ventral spinal cord progenitors
• partial rescue of the spinal cord development phenotype observed in homozygous Gli2tm1Alj mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
|
|
• decrease in number of V3 interneurons that occupy the ventral midline
|
|
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
|
| N |
• almost complete rescue of the pre-axial limb polydactyly observed in Gli3 mutants
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
|
|
• only a very small number of V3 interneurons are seen in the ventral midline of the spinal cord
|
|
• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
