Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm5.1(GLI3)Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
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mortality/aging
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• pups live for only 2 days after birth
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nervous system
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• abnormal spatial patterning of ventral spinal cord progenitors
• partial rescue of the spinal cord development phenotype observed in homozygous Gli2tm1Alj mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2tm5.1(GLI3)Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
Gli3Xt mutation
(1 available);
any
Gli3 mutation
(80 available)
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nervous system
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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• decrease in number of V3 interneurons that occupy the ventral midline
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embryo
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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limbs/digits/tail
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N |
• almost complete rescue of the pre-axial limb polydactyly observed in Gli3 mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli1tm2Alj mutation
(1 available);
any
Gli1 mutation
(48 available)
Gli2tm5.1(GLI3)Alj mutation
(0 available);
any
Gli2 mutation
(169 available)
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nervous system
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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• only a very small number of V3 interneurons are seen in the ventral midline of the spinal cord
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embryo
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• absence of floor plate cells throughout the anterior/posterior (A/P) axis of the spinal cord
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Analysis Tools