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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Actbtm2(Tag)Arge
targeted mutation 2, Argiris Efstratiadis
MGI:3032619
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Actbtm2(Tag)Arge/Actb+ involves: 129S1/Sv MGI:3032633
cn2
 		Actbtm2(Tag)Arge/Actb+
Tg(Hsp70-1-cre)1Arge/0 		involves: 129S1/Sv * C57BL/6J * CBA MGI:3032629


Genotype
MGI:3032633
ht1
Allelic
Composition		 Actbtm2(Tag)Arge/Actb+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm2(Tag)Arge mutation (0 available); any Actb mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased sarcoma incidence ( J:87544 )
• some females developed tumors as a result of cre-independent excision of the floxed neo cassette




Genotype
MGI:3032629
cn2
Allelic
Composition		 Actbtm2(Tag)Arge/Actb+
Tg(Hsp70-1-cre)1Arge/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm2(Tag)Arge mutation (0 available); any Actb mutation (51 available)
Tg(Hsp70-1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leiomyosarcoma incidence ( J:87544 )
• females exhibited uterine leiomyosacromas around 3 months of age

endocrine/exocrine glands
enlarged seminal vesicle ( J:87544 )
• enlarged due to pronounced hyperplasia of smooth muscle layers
enlarged gallbladder ( J:87544 )
• marked dilation in both males and females due to smooth muscle proliferation

liver/biliary system
enlarged gallbladder ( J:87544 )
• marked dilation in both males and females due to smooth muscle proliferation

muscle
abnormal smooth muscle morphology ( J:87544 )
• smooth muscle hyperproliferation in both males and females
increased leiomyosarcoma incidence ( J:87544 )
• females exhibited uterine leiomyosacromas around 3 months of age

reproductive system
enlarged seminal vesicle ( J:87544 )
• enlarged due to pronounced hyperplasia of smooth muscle layers
abnormal uterus morphology ( J:87544 )
• development of leiomyosarcomas in the uterus

growth/size/body
enlarged gallbladder ( J:87544 )
• marked dilation in both males and females due to smooth muscle proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory