reproductive system
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• Background Sensitivity: mean sperm counts for heterozygous males are significantly lower than for wild-type males; substituting CBA/H for C57BL/6J in the background normalizes the sperm count
• lowered sperm count is not signficant enough to be the reason for decreased fertility
• lowered sperm count is associated with reduction in testis weight
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• Background Sensitivity: frequency of sperm-head abnormalities is doubled compared to wild-type; difference was significant only in presence of CBA/H alleles
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• Background Sensitivity: decreased frequency of ring configurations are seen, compared to mice inheriting strain CBA/H alleles
• resolve to chromosomally unbalanced gametes and reduced fertility
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• mean testis weights were significantly reduced compared to wild-type males
• lowered weight is associated with decreased sperm count
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endocrine/exocrine glands
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• mean testis weights were significantly reduced compared to wild-type males
• lowered weight is associated with decreased sperm count
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growth/size/body
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• body-weights are slightly reduced in translocation carriers compared to wild-type siblings
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cellular
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• Background Sensitivity: mean sperm counts for heterozygous males are significantly lower than for wild-type males; substituting CBA/H for C57BL/6J in the background normalizes the sperm count
• lowered sperm count is not signficant enough to be the reason for decreased fertility
• lowered sperm count is associated with reduction in testis weight
|
|
• Background Sensitivity: frequency of sperm-head abnormalities is doubled compared to wild-type; difference was significant only in presence of CBA/H alleles
|
|
• Background Sensitivity: decreased frequency of ring configurations are seen, compared to mice inheriting strain CBA/H alleles
• resolve to chromosomally unbalanced gametes and reduced fertility
|