All Phenotypes Adar<tm1Phs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adar^tm1Phs
targeted mutation 1, Peter H Seeburg
MGI:3029789

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adar^tm1Phs/Adar^tm1Phs	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3029861
hm2	Adar^tm1Phs/Adar^tm1Phs	involves: 129S1/Sv * 129X1/SvJ * NMRI	MGI:3029863

Allelic Composition	Adar^tm1Phs/Adar^tm1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm1Phs mutation (2 available); any Adar mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87715 )

• death between E11.5 and E12.5

embryo

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12

hematopoietic system

absent common myeloid progenitor cells ( J:87715 )

• reduced in the fetal liver

impaired hematopoiesis ( J:87715 )

• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos

liver/biliary system

abnormal liver development ( J:87715 )

• disintegrating liver structure with reduced cell density evident at E11.5

• often blood accumulation in pathologically enlarged spaces

small liver ( J:87715 )

• significant size reduction of fetal liver evident at E12

• fetal liver size was normal until E11-E11.25

growth/size/body

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12

Allelic Composition	Adar^tm1Phs/Adar^tm1Phs
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm1Phs mutation (2 available); any Adar mutation (71 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87715 )

• death between E11.5 and E12.5

embryo

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12

hematopoietic system

absent common myeloid progenitor cells ( J:87715 )

• reduced in the fetal liver

impaired hematopoiesis ( J:87715 )

• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos

liver/biliary system

abnormal liver development ( J:87715 )

• disintegrating liver structure with reduced cell density evident at E11.5

• often blood accumulation in pathologically enlarged spaces

small liver ( J:87715 )

• significant size reduction of fetal liver evident at E12

• fetal liver size was normal until E11-E11.25

growth/size/body

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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