Phenotypes associated with this allele

• Allele Symbol: Bad^tm1Meg
• Allele Name: targeted mutation 1, Michael E Greenberg
• Allele ID: MGI:3029528
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bad^tm1Meg/Bad^tm1Meg	involves: 129S4/SvJae	MGI:3029626

Genotype
MGI:3029626

hm1

• Allelic Composition: Bad^tm1Meg/Bad^tm1Meg
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal apoptosis ( J:88139 )

• increased sensitivity to apoptotic stimuli

• hypersensitive to gamma irradiation

increased pancreatic beta cell apoptosis ( J:133563 )

• beta cells show increased sensitivity to apoptosis

hematopoietic system

small thymus ( J:88139 )

decreased thymus weight ( J:88139 )

thymus hypoplasia ( J:88139 )

• fewer cells in thymus

abnormal B cell differentiation ( J:88139 )

decreased pro-B cell number ( J:88139 )

• reduced numbers in bone marrow

abnormal T cell differentiation ( J:88139 )

• increased proportion of pre-pro T cells (CD44+) but absolute numbers normal

• fewer pro T cells (CD25+)

• proportions of later T cell developmental stages were normal

decreased mature B cell number ( J:88139 )

• reduced number of mature B cells in spleen

immune system

small thymus ( J:88139 )

decreased thymus weight ( J:88139 )

thymus hypoplasia ( J:88139 )

• fewer cells in thymus

abnormal B cell differentiation ( J:88139 )

decreased pro-B cell number ( J:88139 )

• reduced numbers in bone marrow

abnormal T cell differentiation ( J:88139 )

• increased proportion of pre-pro T cells (CD44+) but absolute numbers normal

• fewer pro T cells (CD25+)

• proportions of later T cell developmental stages were normal

decreased mature B cell number ( J:88139 )

• reduced number of mature B cells in spleen

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:133563 )

• beta cells show increased sensitivity to apoptosis

small pancreatic islets ( J:133563 )

• reduced islets area in section from mice on a high fat diet

small thymus ( J:88139 )

decreased thymus weight ( J:88139 )

thymus hypoplasia ( J:88139 )

• fewer cells in thymus

decreased insulin secretion ( J:133563 )

• impaired glucose stimulated insulin secretion

homeostasis/metabolism

decreased insulin secretion ( J:133563 )

• impaired glucose stimulated insulin secretion

increased circulating glucose level ( J:133563 )

• induced by a high fat diet

decreased circulating insulin level ( J:133563 )

• decreased blood insulin levels on a high fat diet

growth/size/body

abnormal body weight ( J:133563 )

• initially lower than controls on a high fat diet becoming equivalent to controls after a few weeks