About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fhl2tm1Chen
targeted mutation 1, Ju Chen
MGI:3029431
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fhl2tm1Chen/Fhl2tm1Chen involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3029432
ht2
 		Fhl2tm1Chen/Fhl2+ involves: 129S1/Sv * 129X1/SvJ MGI:5491822
cx3
 		Fhl2tm1Chen/Fhl2+
Rock2tm1.1Liao/Rock2+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5491823


Genotype
MGI:3029432
hm1
Allelic
Composition		 Fhl2tm1Chen/Fhl2tm1Chen
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl2tm1Chen mutation (0 available); any Fhl2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:64807 )
• homozygous mice exhibit no discernable phenotype; mice are viable and fertile with normal cardiac development and physiology




Genotype
MGI:5491822
ht2
Allelic
Composition		 Fhl2tm1Chen/Fhl2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl2tm1Chen mutation (0 available); any Fhl2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac hypertrophy ( J:196433 )
• augmented hypertrophic response to Ang II
cardiac fibrosis ( J:196433 )
• augmented fibrosis response to Ang II

growth/size/body
cardiac hypertrophy ( J:196433 )
• augmented hypertrophic response to Ang II




Genotype
MGI:5491823
cx3
Allelic
Composition		 Fhl2tm1Chen/Fhl2+
Rock2tm1.1Liao/Rock2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl2tm1Chen mutation (0 available); any Fhl2 mutation (18 available)
Rock2tm1.1Liao mutation (0 available); any Rock2 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:196433 )
N
• hypertrophic and fibrosis responses to Ang II are similar to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory