Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jbd mutation
(0 available);
any
Trpv1 mutation
(59 available)
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nervous system
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• vagal neurons fail to respond to capsaicin unlike similarly treated wild-type mice
• vagal neurons lack response to 100 uM 4-oxononenal (4ONE) unlike similarly treated wild-type cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv1tm1Jbd mutation
(0 available);
any
Trpv1 mutation
(59 available)
|
|
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behavior/neurological
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• while mice did not show a prolonged latency in the hot plate test, they did not develop thermal hyperalgesia after induced inflammation by carrageenan injection
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nervous system
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• cultured small dorsal root ganglion neurons lacked capsaicin-, acid-, and heat-gated responses, but exhibited normal responses to gamma-aminobutyric acid and ATP
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