Phenotypes associated with this allele

• Allele Symbol: Capn5^tm1Nde
• Allele Name: targeted mutation 1, T Neil Dear
• Allele ID: MGI:3029041
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Capn5^tm1Nde/Capn5^tm1Nde	involves: 129X1/SvJ * C57BL/6J	MGI:3029064

Genotype
MGI:3029064

hm1

• Allelic Composition: Capn5^tm1Nde/Capn5^tm1Nde
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87678 )

• a small number survive to 7-8 weeks

• one severely runted female survived to adulthood and was fertile, giving birth to normal offspring

postnatal lethality, incomplete penetrance ( J:87678 )

• most of the severely runted homozygotes died by 3 weeks of age

growth/size/body

decreased body size ( J:87678 )

• although most homozygotes were normal in behavior, morphology, and development, a small number were severely runted at birth

immune system

immune system phenotype ( J:87678 )

N • no abnormalities in T-cells found

N • responses to T-dependent and T-independent antigens were normal

N • no signs of autoimmune disease