Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation
(1 available);
any
Cited1 mutation
(5 available)
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mortality/aging
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• when null males are crossed with heterozygous females, null mutants are underrepresented by 78% compared with controls on P28; further analysis indicates lethality within 1 day after birth
• Background Sensitivity: penetrance is increased with contribution from C57BL/6 genetic background
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embryo
growth/size/body
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• reduction in body weight relative to controls on day of birth
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• weigh significantly less at E18.5 than controls
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cardiovascular system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation
(1 available);
any
Cited1 mutation
(5 available)
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mortality/aging
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• incomplete penetrance, with lethality within 1 day after birth
• Background Sensitivity: penetrance increased with contribution from C57BL/6 genetic background
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embryo
growth/size/body
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• females are 19% lighter than controls at birth, however they reach normal body weight by 160 days of age
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• weigh significantly less at E18.5 than controls
• mice reach normal body weight by 160 days of age
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cardiovascular system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation
(1 available);
any
Cited1 mutation
(5 available)
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mortality/aging
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• loss of heterozygous females at birth (47%) but only when the wild-type allele is inherited from the father
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cellular
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• female heterozygotes that inherit a wild-type paternal allele and mutant maternal allele are phenotypically null in extraembryonic ectoderm and endoderm due to inactivation of the the paternal allele and die at or shortly after birth
• female heterozygotes that inherit a mutant paternal allele and a wild-type maternal allele are phenotypically normal
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embryo
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• border between the spongiotrophoblast and labyrinthine layers is irregular in females inheriting the mutant allele from the mother and the wild-type allele from the father; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
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• fetal vasculature is disrupted in female heterozygotes inheriting the mutant allele from the mother and the wild-type allele from the father due to the projection of spongiotrophoblasts into the labyrinthine layer
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• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants that inherit the mutant allele from the mother and the wild-type allele from the father
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
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growth/size/body
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• birth weight of mice that inherit a mutant maternal allele is reduced
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• weight of mice that inherit a mutant maternal allele is reduced at E18.5
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cardiovascular system
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• fetal vasculature is disrupted in female heterozygotes inheriting the mutant allele from the mother and the wild-type allele from the father due to the projection of spongiotrophoblasts into the labyrinthine layer
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• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants that inherit the mutant allele from the mother and the wild-type allele from the father
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation
(1 available);
any
Cited1 mutation
(5 available)
|
|
|
mortality/aging
 |
• when wild-type males and heterozygous females are crossed, 82% fewer null males are seen at P28; further analysis indicates lethality within 1 day of birth
• Background Sensitivity: penetrance increases with contribution from C57BL/6 genetic background
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embryo
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• border between the spongiotrophoblast and labyrinthine layers is irregular; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
• surface area available for exchange between the fetus and mother is greatly reduced due to increase in size of maternal sinusoids
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• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
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• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
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• increase in the size of the spongiotrophoblast layer, however overall size of the placenta is normal
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• decrease in the size of the labyrinthine layer, however overall size of the placenta is normal
• organization of the labyrinth is disrupted
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growth/size/body
|
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• reduction in body weight relative to controls on day of birth
|
|
|
• weigh significantly less at E18.5 than controls
|
cardiovascular system
|
|
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
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• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
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Allelic
Composition |
Cited1tm1Dunw/Y
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited1tm1Dunw mutation
(1 available);
any
Cited1 mutation
(5 available)
|
|
|
mortality/aging
|
|
• incomplete penetrance; 20% reduction in null mice compared to wild-type
• Background Sensitivity: penetrance increases with contribution from C57BL/6 genetic background
|
embryo
|
|
• border between the spongiotrophoblast and labyrinthine layers is irregular; finger-like projections of spongiotrophoblasts often extend through the labyrinthine layer
• surface area available for exchange between the fetus and mother is greatly reduced due to increase in size of maternal sinusoids
|
|
|
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
|
|
|
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
|
|
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• increase in the size of the spongiotrophoblast layer, however overall size of the placenta is normal
|
|
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• decrease in the size of the labyrinthine layer, however overall size of the placenta is normal
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• organization of the labyrinth is disrupted
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growth/size/body
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• males are 23% lighter than controls at birth, however they reach normal body weight by 160 days of age
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• weigh significantly less at E18.5 than controls
|
cardiovascular system
|
|
• fetal vasculature is disrupted due to the projection of spongiotrophoblasts into the labyrinthine layer
• surface length of trophoblast-lined maternal sinusoids are 62% greater than in controls
|
|
|
• unlike in control placentas where canal branches and anastomosing sinusoids spread out to produce an even circular base, the base is very irregular in mutants
• sinusoids within the labyrinth show less branching and are 2- to 3.5-fold greater in diameter than in controls
|
Analysis Tools