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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elk1tm1Nor
targeted mutation 1, Alfred Nordheim
MGI:3028871
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Elk1tm1Nor/Y
Elk4tm1Rtr/Elk4tm1Rtr 		involves: 129P2/OlaHsd MGI:5790493
cx2
 		Elk1tm1Nor/Elk1tm1Nor
Elk4tm1Rtr/Elk4tm1Rtr 		involves: 129P2/OlaHsd MGI:5790494
ot3
 		Elk1tm1Nor/Y involves: 129P2/OlaHsd * C57BL/6N MGI:3028877


Genotype
MGI:5790493
cx1
Allelic
Composition		 Elk1tm1Nor/Y
Elk4tm1Rtr/Elk4tm1Rtr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1tm1Nor mutation (0 available); any Elk1 mutation (8 available)
Elk4tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:221521 )
N
• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls
• no retinal neovascularization is observed




Genotype
MGI:5790494
cx2
Allelic
Composition		 Elk1tm1Nor/Elk1tm1Nor
Elk4tm1Rtr/Elk4tm1Rtr
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1tm1Nor mutation (0 available); any Elk1 mutation (8 available)
Elk4tm1Rtr mutation (0 available); any Elk4 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:221521 )
N
• adult mice show no apparent changes in retinal arterial shapes, lengths and widths nor in retinal layering and layer thickness relative to wild-type controls
• no retinal neovascularization is observed




Genotype
MGI:3028877
ot3
Allelic
Composition		 Elk1tm1Nor/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elk1tm1Nor mutation (0 available); any Elk1 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:87597 )
N
• normal T-cell maturation
• normal response to coxsackievirus

reproductive system
male infertility ( J:87597 )
• male sterility due probably to aberrant Tk expression in testes

nervous system
nervous system phenotype ( J:87597 )
N
• essentially normal although c-fos expression in the cortex and hippocampal CA1 after kainic acid injection was impaired

cellular




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory