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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ift88fxo
flexo
MGI:3027342
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ift88fxo/Ift88fxo C3.B6J-Ift88fxo MGI:3580671
hm2
 		Ift88fxo/Ift88fxo involves: C3HeB/FeJ * C57BL/6J MGI:3027343
ht3
 		Ift88fxo/Ift88tm1Rpw involves: 129/Sv * C3HeB/FeJ * C57BL/6J MGI:3027344


Genotype
MGI:3580671
hm1
Allelic
Composition		 Ift88fxo/Ift88fxo
Genetic
Background		 C3.B6J-Ift88fxo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88fxo mutation (1 available); any Ift88 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:86437 )
• development is arrested at E12.5-E13.5

nervous system
abnormal floor plate morphology ( J:86437 )
• lack of ventral midline groove in the neural plate
abnormal midbrain morphology ( J:86437 )
• sharp angle to mesencephalic flexure at E9.5-E10.5

limbs/digits/tail
polydactyly ( J:86437 )
• preaxial polydactyly

embryo
abnormal floor plate morphology ( J:86437 )
• lack of ventral midline groove in the neural plate




Genotype
MGI:3027343
hm2
Allelic
Composition		 Ift88fxo/Ift88fxo
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88fxo mutation (1 available); any Ift88 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
absent floor plate ( J:98216 )
• no floor plate in the caudal spinal cord

embryo
abnormal left-right axis patterning ( J:98216 )
• left-right randomization
absent floor plate ( J:98216 )
• no floor plate in the caudal spinal cord

limbs/digits/tail




Genotype
MGI:3027344
ht3
Allelic
Composition		 Ift88fxo/Ift88tm1Rpw
Genetic
Background		 involves: 129/Sv * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ift88fxo mutation (1 available); any Ift88 mutation (46 available)
Ift88tm1Rpw mutation (0 available); any Ift88 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate
abnormal cranial flexure morphology ( J:86437 )
• sharp angle to mesencephalic flexure at E9.5-E10.5

limbs/digits/tail
preaxial polydactyly ( J:86437 )
• preaxial polydactyly

embryo
embryonic growth arrest ( J:86437 )
• development is arrested at E12.5-E13.5
abnormal floor plate morphology ( J:86437 )
• lack the ventral midline groove in the neural plate




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory