Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a2tm3Ling mutation
(1 available);
any
Atp1a2 mutation
(61 available)
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cardiovascular system
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N |
• mice are viable, fertile, and exhibit normal cardiovascular function under normal conditions
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• the oubain-induced inotropy observed in wild-type mice does not occur in mutant oubain-treated hearts
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muscle
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• the oubain-induced inotropy observed in wild-type mice does not occur in mutant oubain-treated hearts
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cardiovascular system
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• ouabain, a glycoside poison that binds to and inhibits the sodium-potassium pump (inhibits Atp1a1 but not Atp1a2 in these mutants), increased cardiac contractility in isolated mutant hearts and resulted in greater positive inotropy than in wild-type
• 3-fold greater increase in the maximal rate of contraction and the rate of contraction at 40 mm Hg than in wild-type after ouabain infusion, however heart function and response of cardiac contraction to beta-adrenergic stimuli was normal under regular conditions (without ouabain)
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muscle
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• ouabain, a glycoside poison that binds to and inhibits the sodium-potassium pump (inhibits Atp1a1 but not Atp1a2 in these mutants), increased cardiac contractility in isolated mutant hearts and resulted in greater positive inotropy than in wild-type
• 3-fold greater increase in the maximal rate of contraction and the rate of contraction at 40 mm Hg than in wild-type after ouabain infusion, however heart function and response of cardiac contraction to beta-adrenergic stimuli was normal under regular conditions (without ouabain)
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Analysis Tools