Phenotypes associated with this allele

• Allele Symbol: Ifi47^tm1Gat
• Allele Name: targeted mutation 1, Gregory A Taylor
• Allele ID: MGI:3027113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifi47^tm1Gat/Ifi47^tm1Gat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3027115

Genotype
MGI:3027115

hm1

• Allelic Composition: Ifi47^tm1Gat/Ifi47^tm1Gat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:87535 )

N • in the absence of infection, homozygotes display normal T cell, B cell, macrophage, and natural killer cell development relative to wild-type control mice

N • in response to i.p. inoculation with 1,000 CFUs of Listeria monocytogenes, homozygotes show normal resistance to bacterial infection, with 100% survival at 40 days after infection and no significant differences in splenic and liver bacterial loads at 3 days after infection relative to wild-type control mice

N • in response to i.p. inoculation with 5 x 10⁴ PFU murine cytomegalovirus (MCMV), homozygotes display normal resistance to viral infection, with no differences in splenic and liver viral loads at 3 days after inoculation relative to wild-type control mice

increased susceptibility to parasitic infection ( J:87535 )

• in response to i.p. inoculation with 20 cysts of Toxoplasma gondii (a parasitic protozoan), homozygotes show only a marginal loss of resistance to the parasite during the chronic phase of infection, with 67% dying between days 10 and 47 whereas wild-type control mice remain viable at 60 days after infection

• a correlation is observed between the burden of T. gondii cysts in infected mutant brains and the partial reduction in survival during the chronic phase of infection

• no differences in IFN-gamma production are observed after exposure to soluble T. gondii tachyzoite extract relative to wild-type control mice