Phenotypes associated with this allele

• Allele Symbol: Gata3^jal
• Allele Name: juvenile alopecia
• Allele ID: MGI:3027100
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata3^jal/Gata3^jal	C3H/HeJ-Gata3^jal/J	MGI:3044115
ht2	Gata3^jal/Gata3^+	C3H/HeJ-Gata3^jal/J	MGI:5432251

Genotype
MGI:3044115

hm1

• Allelic Composition: Gata3^jal/Gata3^jal
• Genetic Background: C3H/HeJ-Gata3^jal/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal hair shaft melanin granule distribution ( J:77437 )

• aberrant melanin incorporation

integument

alopecia ( J:186383 )

• one or more foci of alopecia on the dorsal trunk by 18 days of age

focal dorsal hair loss ( J:77437 )

• patches of hair loss on dorsal surface was noted by 18 days of age; progressive severity to adult

abnormal hair texture ( J:77437 , J:186383 )

• by light microscopy plucked hairs are distorted and broken and by scanning electron microscope they are found bifurcated, grossly distorted and lacking a cuticle (J:186383)

waved hair ( J:77437 , J:186383 )

• truncal hair had a wavy texture (J:77437)

abnormal hair shaft morphology ( J:77437 )

• individual hairs were waved, kinked, bifurcated and/or broken

abnormal hair shaft melanin granule distribution ( J:77437 )

• aberrant melanin incorporation

abnormal hair cuticle ( J:77437 )

• variable absence

abnormal hair follicle morphology ( J:77437 )

• hair follicle dystrophy observed in vibrissae, pelage and eye lid cilia

• anomalies noted in inner root sheath, cuticle and bulb regions

abnormal vibrissa morphology ( J:77437 )

• defects observed at birth and persisted throughout life

curly vibrissae ( J:186383 )

• homozygotoes can be identified shortly after birth by short, curled vibrissae

short vibrissae ( J:186383 )

abnormal hair cycle ( J:77437 )

• patterns of hair growth after depiliation suggest an abnormality in hair cycle regulation

growth/size/body

decreased body size ( J:186383 )

Genotype
MGI:5432251

ht2

• Allelic Composition: Gata3^jal/Gata3⁺
• Genetic Background: C3H/HeJ-Gata3^jal/J

integument

abnormal hair texture ( J:186383 )

• scanning electron microscopy shows focal distortions and breaks, but hairs are normal in appearance