Phenotypes associated with this allele

• Allele Symbol: Nfya^tm1.1Mait
• Allele Name: targeted mutation 1.1, Sankar N Maity
• Allele ID: MGI:3027021
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfya^tm1.1Mait/Nfya^tm1.1Mait	involves: C57BL/6	MGI:3027022
cn2	Nfya^tm1Mait/Nfya^tm1.1Mait	involves: C57BL/6	MGI:3840354

Genotype
MGI:3027022

hm1

• Allelic Composition: Nfya^tm1.1Mait/Nfya^tm1.1Mait
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:87090 )

• lethality before E8.5, as no embryos are seen at this time

Genotype
MGI:3840354

cn2

• Allelic Composition: Nfya^tm1Mait/Nfya^tm1.1Mait
• Genetic Background: involves: C57BL/6

cellular

abnormal cell cycle ( J:87090 )

• embryonic fibroblasts (MEFs) infected with adenovirus expressing Cre recombinase (AdCre) show a marked decrease in the number of cells in S phase compared to controls

• when aphidicolin is used to arrest AdCre infected MEFs at the G1-S boundary and then the cells are released from the block, entry of cells into S phase is decreased (4% of cells) compared to controls (40% of cells)

increased fibroblast apoptosis ( J:87090 )

• MEFs infected with AdCre undergo increased apoptosis compared to control MEFs

decreased fibroblast proliferation ( J:87090 )

• MEFs from E13.5 embryos infected with adenovirus expressing Cre recombinase (AdCre) exhibit a decrease in growth rate in culture