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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spon2tm1Mjb
targeted mutation 1, Michael J Bevan
MGI:3026870
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spon2tm1Mjb/Spon2tm1Mjb involves: 129S6/SvEvTac * C57BL/6 MGI:3027025


Genotype
MGI:3027025
hm1
Allelic
Composition		 Spon2tm1Mjb/Spon2tm1Mjb
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spon2tm1Mjb mutation (0 available); any Spon2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal interleukin level ( J:87393 )
• levels increased very slightly
abnormal tumor necrosis factor level ( J:87393 )
• TNF levels increased very slightly
• production in macrophages reduced
abnormal susceptibility to infection ( J:87393 )
• succeptibility to bacterial infection variable depending on strain

homeostasis/metabolism
abnormal interleukin level ( J:87393 )
• levels increased very slightly
abnormal tumor necrosis factor level ( J:87393 )
• TNF levels increased very slightly
• production in macrophages reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory