Phenotypes associated with this allele

• Allele Symbol: Cd79a^tm2Pld
• Allele Name: targeted mutation 2, Roberta Pelanda
• Allele ID: MGI:2687365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm2Pld/Cd79a^tm2Pld	BALB/c-Cd79a^tm2Pld	MGI:2687385
cx2	Cd79a^tm2Pld/Cd79a^tm2Pld Cd79b^tm1Mnz/Cd79b^tm1Mnz	involves: 129S1/Sv * BALB/c	MGI:2687387

Genotype
MGI:2687385

hm1

• Allelic Composition: Cd79a^tm2Pld/Cd79a^tm2Pld
• Genetic Background: BALB/c-Cd79a^tm2Pld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:87492 )

• 14% of bone marrow cells express B220

• 8.5 % of bone marrow cells express CD19 - a strict marker for B cell lineages

• no bone marrow cells express IgM

• Pro-B cells fail to develop further

• about 10% of spleen cells do express B220

• V_H to DJ_H rearrangement unaffected

abnormal T cell differentiation ( J:87492 )

decreased double-positive T cell number ( J:87492 )

• by about 50%

absent mature B cells ( J:87492 )

• no mature B cells in spleen

immune system

abnormal B cell differentiation ( J:87492 )

• 14% of bone marrow cells express B220

• 8.5 % of bone marrow cells express CD19 - a strict marker for B cell lineages

• no bone marrow cells express IgM

• Pro-B cells fail to develop further

• about 10% of spleen cells do express B220

• V_H to DJ_H rearrangement unaffected

abnormal T cell differentiation ( J:87492 )

decreased double-positive T cell number ( J:87492 )

• by about 50%

absent mature B cells ( J:87492 )

• no mature B cells in spleen

Genotype
MGI:2687387

cx2

• Allelic Composition: Cd79a^tm2Pld/Cd79a^tm2Pld; Cd79b^tm1Mnz/Cd79b^tm1Mnz
• Genetic Background: involves: 129S1/Sv * BALB/c

hematopoietic system

absent pre-B cells ( J:87492 )

• V_H to DJ_H rearrangement unaffected

immune system

absent pre-B cells ( J:87492 )

• V_H to DJ_H rearrangement unaffected