About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RereGt(PTO26)1Byg
gene trap PTO26, BayGenomics
MGI:2687216
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RereGt(PTO26)1Byg/RereGt(PTO26)1Byg involves: 129P2/OlaHsd MGI:3026627
ht2
 		Rereom/RereGt(PTO26)1Byg involves: 129P2/OlaHsd * BTBR * C57BL/6J MGI:3026628


Genotype
MGI:3026627
hm1
Allelic
Composition		 RereGt(PTO26)1Byg/RereGt(PTO26)1Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RereGt(PTO26)1Byg mutation (0 available); any Rere mutation (210 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:87046 )
• no homozygous pups were ever born

embryo
embryo phenotype ( J:87046 )
N
• this is a hypomorphic allele and expression in homozygotes varied from very severe as seen in Rere homozygotes to apparently normal but embryonically lethal




Genotype
MGI:3026628
ht2
Allelic
Composition		 Rereom/RereGt(PTO26)1Byg
Genetic
Background		 involves: 129P2/OlaHsd * BTBR * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RereGt(PTO26)1Byg mutation (0 available); any Rere mutation (210 available)
Rereom mutation (0 available); any Rere mutation (210 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:87046 )
• regular ratio of homozygotes at E9.5
• by E11.5 no mutant embryos found
• death due to cardiac failure shortly after E9.5

cardiovascular system
failure of heart looping ( J:87046 )
• heart tube fails to loop

embryo
abnormal embryonic tissue morphology ( J:87046 )
• abnormalities appear by E8.25
small first pharyngeal arch ( J:87046 )
• first branchial arch reduced in size with a deficit in mesenchyme
open neural tube ( J:87046 )
• failure of the anterior neural tube to close

nervous system
open neural tube ( J:87046 )
• failure of the anterior neural tube to close
abnormal telencephalon development ( J:87046 )
• fusion of telencephalic and optic vesicles

vision/eye
abnormal optic vesicle formation ( J:87046 )
• fusion of telencephalic and optic vesicles

craniofacial
small first pharyngeal arch ( J:87046 )
• first branchial arch reduced in size with a deficit in mesenchyme




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory