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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		RereGt(PTO26)1Byg
gene trap PTO26, BayGenomics
MGI:2687216
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		RereGt(PTO26)1Byg/RereGt(PTO26)1Byg involves: 129P2/OlaHsd MGI:3026627
ht2
 		Rereom/RereGt(PTO26)1Byg involves: 129P2/OlaHsd * BTBR * C57BL/6J MGI:3026628


Genotype
MGI:3026627
hm1
Allelic
Composition		 RereGt(PTO26)1Byg/RereGt(PTO26)1Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RereGt(PTO26)1Byg mutation (0 available); any Rere mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:87046 )
• no homozygous pups were ever born

embryo
embryo phenotype ( J:87046 )
N
• this is a hypomorphic allele and expression in homozygotes varied from very severe as seen in Rere homozygotes to apparently normal but embryonically lethal




Genotype
MGI:3026628
ht2
Allelic
Composition		 Rereom/RereGt(PTO26)1Byg
Genetic
Background		 involves: 129P2/OlaHsd * BTBR * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RereGt(PTO26)1Byg mutation (0 available); any Rere mutation (212 available)
Rereom mutation (0 available); any Rere mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:87046 )
• regular ratio of homozygotes at E9.5
• by E11.5 no mutant embryos found
• death due to cardiac failure shortly after E9.5

cardiovascular system
failure of heart looping ( J:87046 )
• heart tube fails to loop

embryo
abnormal embryonic tissue morphology ( J:87046 )
• abnormalities appear by E8.25
small first pharyngeal arch ( J:87046 )
• first branchial arch reduced in size with a deficit in mesenchyme
open neural tube ( J:87046 )
• failure of the anterior neural tube to close

nervous system
open neural tube ( J:87046 )
• failure of the anterior neural tube to close
abnormal telencephalon development ( J:87046 )
• fusion of telencephalic and optic vesicles

vision/eye
abnormal optic vesicle formation ( J:87046 )
• fusion of telencephalic and optic vesicles

craniofacial
small first pharyngeal arch ( J:87046 )
• first branchial arch reduced in size with a deficit in mesenchyme




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory