Phenotypes associated with this allele
Allelic Composition |
Rereom/Rereom
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Genetic Background |
involves: BTBR * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
|
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mortality/aging
|
• regular ratio of homozygotes at E9.5
• by E11.5 no mutant embryos found
• death due to cardiac failure shortly after E9.5
|
cardiovascular system
|
• heart tube fails to loop
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embryo
|
• abnormalities appear by E8.25
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• first branchial arch reduced in size with a deficit in mesenchyme
|
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• failure of anterior neural tube to close
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nervous system
|
• failure of anterior neural tube to close
|
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• fusion of telencephalic and optic vesicles
|
vision/eye
|
• fusion of telencephalic and optic vesicles
|
craniofacial
|
• first branchial arch reduced in size with a deficit in mesenchyme
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereeyes3 mutation
(0 available);
any
Rere mutation
(212 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
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Cardiovascular malformations in Rereom/Rereeyes3 embryos on a C57BL6 background
mortality/aging
|
• on a B6 background, mice are reported to exhibit perinatal lethality with no pups recovered at P0
• however, fetuses are found at Mendelian ratios at E15.5
|
cardiovascular system
|
• Background Sensitivity: cardiovascular malformation in 6 of 6 mice on a congenic C57BL/6 background unlike mice on a mixed background
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• in the myocardium of the ventricle wall of adult mice
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renal/urinary system
craniofacial
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• at E15.5, palate shelves fail to contact each other in the midline
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• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
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digestive/alimentary system
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• at E15.5, palate shelves fail to contact each other in the midline
|
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• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
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growth/size/body
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• at E15.5, palate shelves fail to contact each other in the midline
|
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• at E15.5, cleft palate is detected in the midline from the anterior region to the posterior region in 80% of mice
|
endocrine/exocrine glands
N |
• mice with renal agenesis exhibit normal adrenal glands
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RereGt(PTO26)1Byg mutation
(0 available);
any
Rere mutation
(212 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
|
|
mortality/aging
|
• regular ratio of homozygotes at E9.5
• by E11.5 no mutant embryos found
• death due to cardiac failure shortly after E9.5
|
cardiovascular system
|
• heart tube fails to loop
|
embryo
|
• abnormalities appear by E8.25
|
|
• first branchial arch reduced in size with a deficit in mesenchyme
|
|
• failure of the anterior neural tube to close
|
nervous system
|
• failure of the anterior neural tube to close
|
|
• fusion of telencephalic and optic vesicles
|
vision/eye
|
• fusion of telencephalic and optic vesicles
|
craniofacial
|
• first branchial arch reduced in size with a deficit in mesenchyme
|
Allelic Composition |
Rereeyes3/Rereom
|
|
Genetic Background |
involves: 129S6/SvEvTac * BTBR * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rereeyes3 mutation
(0 available);
any
Rere mutation
(212 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
|
|
Severe microphthalmia in Rereeyes3/Rereom mice
mortality/aging
|
• despite being born in Mendelian ratios, most mice die before weaning
|
nervous system
N |
• neuron proliferation, apoptosis and maturation of granule cells are normal
|
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• reduced surface area of the cerebral hemispheres at E17.0 and P0
|
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• decreased NeuN+ hippocampal neurons at E18.5 in the Ammon's horn
• however, the number of NeuN+ neurons in the dentate gyrus is normal
|
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• reduced surface area of the cerebellum at E17.0 and P0
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hearing/vestibular/ear
growth/size/body
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• despite normal birth weight, mice weight less at P7 compared with wild-type mice
|
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• body weights plateau at 6 weeks of age unlike wild-type mice
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vision/eye
|
• unilateral or bilateral; more severe than in Rereeyes3 homozygotes
|
cardiovascular system
N |
• mice on a mixed background exhibit normal cardiovascular morphology unlike mice on a congenic C57BL/6 background
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atn1tm1.1Asp mutation
(0 available);
any
Atn1 mutation
(49 available)
Rereom mutation
(0 available);
any
Rere mutation
(212 available)
|
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normal phenotype
|
• compound mutant mice are viable and fertile
|