Phenotypes associated with this allele

• Allele Symbol: Inpp5a⁺
• Allele Name: wild type
• Allele ID: MGI:2686962
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Inpp5a^em1(IMPC)Tcp/Inpp5a^+	C57BL/6NCrl-Inpp5a^em1(IMPC)Tcp/Tcp	MGI:7414929
ht2	Inpp5a^Gt(OST50073)Lex/Inpp5a^+	involves: 129S5/SvEvBrd * C57BL/6J	MGI:6115582

Genotype
MGI:7414929

ht1

• Allelic Composition: Inpp5a^em1(IMPC)Tcp/Inpp5a⁺
• Genetic Background: C57BL/6NCrl-Inpp5a^em1(IMPC)Tcp/Tcp

Data Sources

IMPC Data for Inpp5a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - TCP

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

decreased lean body mass ( J:211773 )

IMPC - TCP

homeostasis/metabolism

edema ( J:211773 )

IMPC - TCP

Genotype
MGI:6115582

ht2

• Allelic Composition: Inpp5a^{Gt(OST50073)Lex}/Inpp5a⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

behavior/neurological

impaired coordination ( J:249381 )

• although no ataxia is apparent at P45, heterozygotes show a 55% reduction in their ability to remain on an accelerating rotarod relative to wild-type controls, indicating a motor deficit

• however, no Purkinje cell loss or abnormal cerebellum morphology are observed

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:249381 )

• in the neonatal cerebellum, phosphatase activity toward soluble phosphoinositol substrates is reduced to an intermediate level relative to homozygotes