Phenotypes associated with this allele

• Allele Symbol: Del(11Jmjd6-Mettl23)1Flv
• Allele Name: deletion, Chr 11, Richard A Flavell 1
• Allele ID: MGI:2686850
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(11Jmjd6-Mettl23)1Flv/Del(11Jmjd6-Mettl23)1Flv	involves: 129S6/SvEvTac * C57BL/6	MGI:2686883

Genotype
MGI:2686883

hm1

• Allelic Composition: Del(11Jmjd6-Mettl23)1Flv/Del(11Jmjd6-Mettl23)1Flv
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:86771 )

• homozygous embryos present at normal ratios at E17.5

• homozygous pups are present at birth but die within a few hours

• no homozygotes survive to day 8

homeostasis/metabolism

abnormal blood homeostasis ( J:86771 )

cyanosis ( J:86771 )

• cyanotic skin color at birth

respiratory system

abnormal lung development ( J:86771 )

• lungs were never fully expanded

• apoptotic cells in lungs at birth but no phagocytosis occurring

respiratory failure ( J:86771 )

• newborn mice unable to breathe

nervous system

abnormal brain development ( J:86771 )

• 15% of homozygotes display brain dysmorphology

• show varying structural abnormalities

• ectopic neuronal proliferation

• apparent inflammatory respon se in the midbrain, failure to phagocytize apoptotic cells

exencephaly ( J:86771 )