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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Malt1+
wild type
MGI:2684758
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Malt1m1Btlr/Malt1+ C57BL/6J-Malt1m1Btlr MGI:5641239
ht2
 		Malt1m2Btlr/Malt1+ C57BL/6J-Malt1m2Btlr MGI:5688634
ht3
 		Malt1m3Btlr/Malt1+ C57BL/6J-Malt1m3Btlr MGI:5688641


Genotype
MGI:5641239
ht1
Allelic
Composition		 Malt1m1Btlr/Malt1+
Genetic
Background		 C57BL/6J-Malt1m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m1Btlr mutation (0 available); any Malt1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired humoral immune response ( J:221474 )
• mice exhibited diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) compared to wild-type, but not as severe as homozygote




Genotype
MGI:5688634
ht2
Allelic
Composition		 Malt1m2Btlr/Malt1+
Genetic
Background		 C57BL/6J-Malt1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m2Btlr mutation (0 available); any Malt1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished

hematopoietic system
decreased IgM level ( J:224671 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




Genotype
MGI:5688641
ht3
Allelic
Composition		 Malt1m3Btlr/Malt1+
Genetic
Background		 C57BL/6J-Malt1m3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Malt1m3Btlr mutation (0 available); any Malt1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished
impaired humoral immune response ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished

hematopoietic system
decreased IgM level ( J:224672 )
• T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) is diminished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory