All Phenotypes Siah2<tm1Ddlb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Siah2^tm1Ddlb
targeted mutation 1, David D L Bowtell
MGI:2683932

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae	MGI:3761116
hm2	Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae * C57BL/6J	MGI:2684006
cx3	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S1/Sv * 129S4/SvJae	MGI:3761117
cx4	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2⁺	involves: 129S4/SvJae * C57BL/6J	MGI:2684007
cx5	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb	involves: 129S4/SvJae * C57BL/6J	MGI:2684008

Allelic Composition	Siah2^tm1Ddlb/Siah2^tm1Ddlb
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siah2^tm1Ddlb mutation (0 available); any Siah2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:126183 )

N	• mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation

Allelic Composition	Siah2^tm1Ddlb/Siah2^tm1Ddlb
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siah2^tm1Ddlb mutation (0 available); any Siah2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal bone marrow morphology ( J:86820 )

• expanded myeloid progenitor compartement in bone marrow by semisolid colony forming cell assay

• expanded potential for osteoclast formation in vitro but not in vivo

Allelic Composition	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb
Genetic Background	involves: 129S1/Sv * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siah1a^tm1Ddlb mutation (0 available); any Siah1a mutation (15 available)
Siah2^tm1Ddlb mutation (0 available); any Siah2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

cellular phenotype ( J:126183 )

N	• mouse embryonic fibroblasts display normal proliferation, contact inhibition, senescence, p53-mediated apoptosis and response to radiation

Allelic Composition	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:86820 )

• most pups die within the first day; all are dead by day 5

postnatal lethality, complete penetrance ( J:86820 )

• all are dead by day 5

Allelic Composition	Siah1a^tm1Ddlb/Siah1a^tm1Ddlb Siah2^tm1Ddlb/Siah2^tm1Ddlb
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:86820 )

• pups die within hours of birth; cause of death unknown

prenatal lethality, incomplete penetrance ( J:86820 )

• homozygotes are born at below expected frequency

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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