All Phenotypes Chst4<tm1Sdr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chst4^tm1Sdr
targeted mutation 1, Steven D Rosen
MGI:2682796

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst4^tm1Sdr/Chst4^tm1Sdr	involves: C57BL/6	MGI:2682836
cx2	Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr	involves: 129S2/SvPas	MGI:5543509
cx3	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr	involves: 129S2/SvPas * C57BL/6NTac	MGI:5543506

Allelic Composition	Chst4^tm1Sdr/Chst4^tm1Sdr
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst4^tm1Sdr mutation (1 available); any Chst4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:86759 )

• homing of labelled lymphocytes to peripheral and mesenteric lymph nodes significantly reduced

• homing of lymphocytes to Peyer's patches and spleen normal

abnormal leukocyte adhesion ( J:86759 )

• adherance to high endothelial venules almost completely lost

abnormal lymph node morphology ( J:86759 )

• in peripheral lymph nodes, lymphocytes reduced 65%

• peripheral lymph nodes reduced in size

abnormal lymph node primary follicle morphology ( J:86759 )

• primary follicles present though smaller than normal

cellular

abnormal leukocyte migration ( J:86759 )

• homing of labelled lymphocytes to peripheral and mesenteric lymph nodes significantly reduced

• homing of lymphocytes to Peyer's patches and spleen normal

abnormal leukocyte adhesion ( J:86759 )

• adherance to high endothelial venules almost completely lost

hematopoietic system

abnormal leukocyte migration ( J:86759 )

• homing of labelled lymphocytes to peripheral and mesenteric lymph nodes significantly reduced

• homing of lymphocytes to Peyer's patches and spleen normal

abnormal leukocyte adhesion ( J:86759 )

• adherance to high endothelial venules almost completely lost

Allelic Composition	Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst2^tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4^tm1Sdr mutation (1 available); any Chst4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal leukocyte migration ( J:204813 )

• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

hematopoietic system

abnormal leukocyte migration ( J:204813 )

• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

immune system

abnormal leukocyte migration ( J:204813 )

• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

Allelic Composition	Chst1^{tm1(KOMP)Vlcg}/Chst1^{tm1(KOMP)Vlcg} Chst2^tm1Tmu/Chst2^tm1Tmu Chst4^tm1Sdr/Chst4^tm1Sdr
Genetic Background	involves: 129S2/SvPas * C57BL/6NTac
Cell Lines	10172A-D6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1^{tm1(KOMP)Vlcg} mutation (2 available); any Chst1 mutation (20 available)
Chst2^tm1Tmu mutation (1 available); any Chst2 mutation (21 available)
Chst4^tm1Sdr mutation (1 available); any Chst4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

cellular

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

hematopoietic system

abnormal leukocyte migration ( J:204813 )

• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice

• however, homing to mesenteric lymph nodes is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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