Phenotypes associated with this allele

• Allele Symbol: Nanos3^tm1Ysa
• Allele Name: targeted mutation 1, Yumiko Saga
• Allele ID: MGI:2682607
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanos3^tm1Ysa/Nanos3^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:2682627

Genotype
MGI:2682627

hm1

• Allelic Composition: Nanos3^tm1Ysa/Nanos3^tm1Ysa
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small ovary ( J:86522 )

♀

decreased testis weight ( J:86522 )

♂ • mutant testes were approximately 30% the weight of those of wild-type

reproductive system

azoospermia ( J:86522 )

♂

decreased primordial germ cell number ( J:86522 )

• while the number of primordial germ cells was similar to that of wild-type at E7.5, the population was not maintained and was observed to be decreased at later developmental stages

• increased apoptosis was undetected

absent germ cells ( J:86522 )

• no germ cells were detected in either the ovaries or testes at E15.5

small gonad ( J:86522 )

small ovary ( J:86522 )

♀

decreased testis weight ( J:86522 )

♂ • mutant testes were approximately 30% the weight of those of wild-type

female infertility ( J:86522 )

♀

male infertility ( J:86522 )

♂

cellular

azoospermia ( J:86522 )

♂

decreased primordial germ cell number ( J:86522 )

• while the number of primordial germ cells was similar to that of wild-type at E7.5, the population was not maintained and was observed to be decreased at later developmental stages

• increased apoptosis was undetected

absent germ cells ( J:86522 )

• no germ cells were detected in either the ovaries or testes at E15.5