Phenotypes associated with this allele

• Allele Symbol: Pdgfrb^tm8Sor
• Allele Name: targeted mutation 8, Philippe Soriano
• Allele ID: MGI:2682376
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfrb^tm8Sor/Pdgfrb^tm8Sor	involves: 129S4/SvJae * C57BL/6	MGI:2682401
ht2	Pdgfrb^tm1Sor/Pdgfrb^tm8Sor	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:4421852

Genotype
MGI:2682401

hm1

• Allelic Composition: Pdgfrb^tm8Sor/Pdgfrb^tm8Sor
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:86542 )

• vascular defects in eyes, hearts and brains; no defects in kidney mesangial cells and pericytes in the skin and skeletal muscle

• mutants exhibit abnormalities in the vascular coating of their coronary arteries and veins

abnormal kidney vasculature morphology ( J:86542 )

• decrease in pericytes in the kidney

abnormal pericyte morphology ( J:86542 )

• decrease in incidence of pericytes in the spinal cord, heart and kidney, compared to wild-type

renal/urinary system

abnormal kidney vasculature morphology ( J:86542 )

• decrease in pericytes in the kidney

abnormal renal glomerulus morphology ( J:86542 )

• modest decrease in the number of nuclei in kidney glomeruli but no glomerulosclerosis is seen

Genotype
MGI:4421852

ht2

• Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb^tm8Sor
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

cardiovascular system

abnormal blood vessel morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal pericyte morphology ( J:86542 )

• 70-92% decrease in pericytes in the kidney, heart, and eye

abnormal heart morphology ( J:86542 )

• heart abnormalities

dilated heart atrium ( J:86542 )

increased heart ventricle size ( J:86542 )

cardiac fibrosis ( J:86542 )

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

vision/eye

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

abnormal eye morphology ( J:86542 )

• severe eye defects

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

eye opacity ( J:86542 )