Phenotypes associated with this allele

• Allele Symbol: Msh2^tm1Wed
• Allele Name: targeted mutation 1, Winfried Edelmann
• Allele ID: MGI:2680817
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh2^tm1Wed/Msh2^tm1Wed	involves: 129 * C57BL/6 * SJL	MGI:3036547
hm2	Msh2^tm1Wed/Msh2^tm1Wed	involves: C57BL/6	MGI:2680823

Genotype
MGI:3036547

hm1

• Allelic Composition: Msh2^tm1Wed/Msh2^tm1Wed
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:88092 )

• while greater than 90% survive to 6 months of age and more than 60% survive to 9 months, all die by 12 months of age, due to cancer

premature death ( J:88092 )

• while greater than 90% survive to 6 months of age and more than 60% survive to 9 months, all die by 12 months of age

neoplasm

increased tumor incidence ( J:88092 )

• tumors are responsive to treatment with a chemotherapeutic agent, unlike Msh2 null tumors

increased intestinal adenocarcinoma incidence ( J:88092 )

• develops in 19% of mice between 7 and 10 months of age

increased lymphoma incidence ( J:88092 )

• non-Hodgkin's lymphoma develops in 63% of mice between 9 and 12 months of age

increased tumor latency ( J:88092 )

• the onset of tumorigenesis is delayed compared to Msh2 null mice

cellular

abnormal mismatch repair ( J:88092 )

• ES cell extracts are unable to repair substrates containing G-G mismatches, single-base insertion/deletion mismatches or 2-base insertion/deletion mismatches with a nick either 3' or 5' to the mismatched base

homeostasis/metabolism

abnormal mismatch repair ( J:88092 )

• ES cell extracts are unable to repair substrates containing G-G mismatches, single-base insertion/deletion mismatches or 2-base insertion/deletion mismatches with a nick either 3' or 5' to the mismatched base

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:88092 )

• develops in 19% of mice between 7 and 10 months of age

Genotype
MGI:2680823

hm2

• Allelic Composition: Msh2^tm1Wed/Msh2^tm1Wed
• Genetic Background: involves: C57BL/6

neoplasm

increased intestinal adenocarcinoma incidence ( J:86278 )

• prone to gastrointestinal adenocarcinomas

increased lymphoma incidence ( J:86278 )

• prone to increased B and T cell lymphomas

immune system

abnormal class switch recombination ( J:86278 )

• class switch recombination is reduced

• mu - gamma 3 switch junctions are longer

• mutation frequencies are lower, due probably to a deficiency of A-T mutations

decreased IgG level ( J:86278 )

• immunogen specific IgG1 levels are lower than in controls

hematopoietic system

abnormal class switch recombination ( J:86278 )

• class switch recombination is reduced

• mu - gamma 3 switch junctions are longer

• mutation frequencies are lower, due probably to a deficiency of A-T mutations

decreased IgG level ( J:86278 )

• immunogen specific IgG1 levels are lower than in controls

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:86278 )

• prone to gastrointestinal adenocarcinomas