Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation
(1 available);
any
Plcb3 mutation
(49 available)
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behavior/neurological
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• mutants are more sensitive to antinociceptive effects of morphine than wild-type mice
• mutants show a 5-fold increased sensitivity to morphine as measured by antinociception in hot plate tail-flick assay
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb3tm1Dwu mutation
(1 available);
any
Plcb3 mutation
(49 available)
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integument
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• at 6 months or older behind the ears, on the next, or sometimes on the face
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immune system
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• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
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• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice
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integument
hematopoietic system
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• neutrophils exhibit increased chemotactic activities in response to CC chemokine MIP-1alpha (Ccl3) compared with similarly treated wild-type cells
• in E. coli-induced peritonitis, neutrophil infiltration into the peritoneal cavity is enhanced compared to in similarly treated wild-type mice
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• mice treated with NP-Ficoll produce more antibodies containing lambda light chain compared with similarly treated wild-type mice
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homeostasis/metabolism
hematopoietic system
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• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
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• thrombin- or ADP-stimulated calcium mobilization in platelets is decreased 58% and 43%, respectively, compared to in similarly treated wild-type cells
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• spreading of platelets on fibrinogen is impaired compared with wild-type cell
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• at low doses of ADP, thrombin, or collagen
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cellular
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• collagen-mediated platelet secretion is mildly enhanced compared to in similarly treated wild-type cells
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