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Allele Symbol Allele Name Allele ID |
Tg(Ins2-HA)165Bri transgene insertion 165, Ralph Brinster MGI:2680173 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• autoimmune diabetes developed with accelerated kinetics
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:85985 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neonates die within 7 to 10 days of birth due to complications in glucose metabolism
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• one day old mice exhibit hyperglycemia with blood glucose levels averaging over 400 mg/dl
• neonates die within 7 to 10 days of birth due to complications in glucose metabolism
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• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters
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• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells
• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neonates die within 7-10 days of birth
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• neonates exhibit hyperglycemia
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• animals display a loss of islet mass and dissemination of remaining islet beta-cell clusters
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• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions
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• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit no evidence of autoimmunity
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• following priming with HA peptides
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• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA
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| N |
• islet beta cells exhibit normal morphology
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• following priming with HA peptides
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• mice exhibit decreased HA-specific response compared with wild-type mice
• however, mice that are irradiated and transplanted with wild-type lymphocyte mount a CD4+ T cells response to HA
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• following priming with HA peptides
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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