Analysis Tools
hematopoietic system
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• 3- to 5-fold reduction in peritoneal B-1a B cells
• however, numbers of total cells and B cells in the bone marrow and spleen are normal
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• B cells are defective in T cell-independent, but not in T cell-dependent, responses to antigen
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• proliferative response of B cells to anti-IgM stimulation, but not LPS, anti-CD40, anti-CD40+IL-4, anti-RP105, anti-CD38 and CpG, is severely impaired
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• IgG3 response is reduced 14-fold in response to NP-Ficoll immunization
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• IgM response is reduced 2- to 3-fold in response to NP-Ficoll immunization
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immune system
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• 3- to 5-fold reduction in peritoneal B-1a B cells
• however, numbers of total cells and B cells in the bone marrow and spleen are normal
|
|
• B cells are defective in T cell-independent, but not in T cell-dependent, responses to antigen
|
|
• proliferative response of B cells to anti-IgM stimulation, but not LPS, anti-CD40, anti-CD40+IL-4, anti-RP105, anti-CD38 and CpG, is severely impaired
|
|
• IgG3 response is reduced 14-fold in response to NP-Ficoll immunization
|
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• IgM response is reduced 2- to 3-fold in response to NP-Ficoll immunization
|
cellular
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• proliferative response of B cells to anti-IgM stimulation, but not LPS, anti-CD40, anti-CD40+IL-4, anti-RP105, anti-CD38 and CpG, is severely impaired
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