All Phenotypes Tsix<tm1Enl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tsix^tm1Enl
targeted mutation 1, En Li
MGI:2679786

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tsix^tm1Enl/Tsix⁺	involves: 129S4/SvJae	MGI:2680289
cx2	Tsix^tm1Enl/Tsix⁺ Xist^tm1Jae/Xist⁺	involves: 129S4/SvJae	MGI:2680291
cx3	Tsix^tm1Enl/Tsix⁺ Xist^tm1Sado/Xist⁺	involves: 129S4/SvJae	MGI:3603005
ot4	Tsix^tm1Enl/?	involves: 129S4/SvJae	MGI:2680286

Allelic Composition	Tsix^tm1Enl/Tsix⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:68136 )

• 3-4X increase of apoptotic cells in colons after injury but not when there is no injury

Allelic Composition	Tsix^tm1Enl/Tsix⁺ Xist^tm1Jae/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)
Xist^tm1Jae mutation (0 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:68136 )

• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5

• gastrulation was apparently normal however

• remaining embryos were grossly normal in size and morphology

growth/size/body

decreased embryo size ( J:68136 )

• 7 of 13 embryos were significantly smaller than normal at E8.5 and E9.5

• gastrulation was apparently normal however

• remaining embryos were grossly normal in size and morphology

Allelic Composition	Tsix^tm1Enl/Tsix⁺ Xist^tm1Sado/Xist⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)
Xist^tm1Sado mutation (1 available); any Xist mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:99399 )

• females that have both mutations on the paternal X chromosome die soon after implantation; however, females that have both mutations on the maternal X chromosome are viable and fertile

Allelic Composition	Tsix^tm1Enl/?
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsix^tm1Enl mutation (1 available); any Tsix mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:68136 )

• only 1 male and 1 female carrier born out of 104 mice

embryo

abnormal developmental patterning ( J:68136 )

abnormal gastrulation ( J:68136 )

abnormal germ layer development ( J:68136 )

abnormal mesoderm development ( J:68136 )

• at E7.5 mesoderm localized primarily at the embyonic/extraembryonic junction

absent egg cylinders ( J:68136 )

• at E6.5 failed to form well organized egg cylinder although all appropriate primitive tissues present

abnormal ectoplacental cone morphology ( J:68136 )

• at E7.5 the ectoplacental cone cells failed to expand into decidual tissue

abnormal allantois morphology ( J:68136 )

• disorganized at E8.5

small amniotic cavity ( J:68136 )

• at E6.5, the amniotic cavity is small

abnormal chorion morphology ( J:68136 )

• disorganized at E8.5

abnormal ectoplacental cavity morphology ( J:68136 )

• at E7.5, the ectoplacental cavity is small

abnormal extraembryonic coelom morphology ( J:68136 )

• at E7.5, exocoelom small and by E8.5 contains dead cells

abnormal visceral yolk sac morphology ( J:68136 )

• at E8.5, sometimes enlarged and containing disorganized embryonic tissue

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