Phenotypes associated with this allele

• Allele Symbol: Slc19a1^tm1Gold
• Allele Name: targeted mutation 1, I David Goldman
• Allele ID: MGI:2679677
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc19a1^tm1Gold/Slc19a1^tm1Gold	involves: 129/Sv * C57BL/6 * SJL	MGI:2679680

Genotype
MGI:2679680

hm1

• Allelic Composition: Slc19a1^tm1Gold/Slc19a1^tm1Gold
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Slc19a1^tm1Gold/Slc19a1^tm1Gold embryos are small and deformed at E9.5

mortality/aging

postnatal lethality, complete penetrance ( J:68666 )

• maternal folic acid supplementation extends embryonic development and ~20% of these mice are born, though they die within 12 days of birth

embryonic lethality, complete penetrance ( J:68666 )

• unsupplemented embyros die prior to E9.5

embryo

embryonic growth retardation ( J:68666 )

• unsupplemented embryos are growth retarded at E9.5

growth/size/body

embryonic growth retardation ( J:68666 )

• unsupplemented embryos are growth retarded at E9.5

decreased body weight ( J:68666 )

• body weights of neonates maternally supplemented with folic acid are significantly lower than in wild-type

postnatal growth retardation ( J:68666 )

• mice maternally supplemented with folic acid show growth retardation after the first few days of life

hematopoietic system

abnormal hematopoietic system morphology/development ( J:68666 )

• hematopoietic organ abnormalities are the putative cause of death of untreated embryos

small thymus ( J:68666 )

• mice maternally supplemented with folic acid have an extremely small thymus

abnormal erythropoiesis ( J:68666 )

• neonates maternally supplemented with folic acid show no erythropoiesis

abnormal lymphopoiesis ( J:68666 )

• mice maternally supplemented with folic acid show lymphoid depletion in splenic white pulp and thymus

impaired hematopoiesis ( J:68666 )

• mice maternally supplemented with folic acid show a marked absence of hematopoiesis in the bone marrow and absence of extramedullary hematopoiesis in the spleen and liver

decreased lymphocyte cell number ( J:68666 )

• mice maternally supplemented with folic acid show marked diminishment of the lymphocyte population in splenic white pulp and thymus

small spleen ( J:68666 )

• mice maternally supplemented with folic acid have extremely small spleens

endocrine/exocrine glands

small thymus ( J:68666 )

• mice maternally supplemented with folic acid have an extremely small thymus

abnormal seminiferous tubule morphology ( J:68666 )

♂ • mice maternally supplemented with folic acid show impaired postnatal development of the seminiferous tubules

immune system

small thymus ( J:68666 )

• mice maternally supplemented with folic acid have an extremely small thymus

abnormal lymphopoiesis ( J:68666 )

• mice maternally supplemented with folic acid show lymphoid depletion in splenic white pulp and thymus

decreased lymphocyte cell number ( J:68666 )

• mice maternally supplemented with folic acid show marked diminishment of the lymphocyte population in splenic white pulp and thymus

small spleen ( J:68666 )

• mice maternally supplemented with folic acid have extremely small spleens

renal/urinary system

abnormal kidney development ( J:68666 )

• mice maternally supplemented with folic acid show impaired postnatal development of renal medullary tubules

reproductive system

abnormal seminiferous tubule morphology ( J:68666 )

♂ • mice maternally supplemented with folic acid show impaired postnatal development of the seminiferous tubules

liver/biliary system

pale liver ( J:68666 )

• mice maternally supplemented with folic acid have pale livers

integument

pallor ( J:68666 )

• mice maternally supplemented with folic acid are pale