Phenotypes associated with this allele

• Allele Symbol: Plcl2^tm1Tta
• Allele Name: targeted mutation 1, Tadaomi Takenawa
• Allele ID: MGI:2679632
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plcl2^tm1Tta/Plcl2^tm1Tta	involves: 129P2/OlaHsd	MGI:2679634

Genotype
MGI:2679634

hm1

• Allelic Composition: Plcl2^tm1Tta/Plcl2^tm1Tta
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:85960 )

• slight, but significant, reduction in mature recirculating B cells in the bone marrow

decreased B-1a cell number ( J:85960 )

• reduction of B-1a cells in the peritoneal cavity, restricted to the CD5+ IgM+ B-1a population

abnormal adaptive immunity ( J:85960 )

• increase in T cell-independent antigen response; when mutants are immunized with T-I antigens, they show a significant increase of anti-TNP, IgM, IgG1, and IgG3 compared to wild-type, indicating enhanced T-I immune responses

abnormal B cell physiology ( J:85960 )

• in the presence of extracellular calcium, a greater calcium influx is seen in mature B cells than in wild-type, indicating enhanced calcium mobilization

increased B cell proliferation ( J:85960 )

• B2 cells develop normally but mature B cells are hyperproliferative in response to B cell receptor cross-linking or anti-IgM F(ab')2 stimulation

increased IgM level ( J:85960 )

• aged (6-7 months old), but not young, mice have a slight, but significant, increase of serum IgM

increased anti-nuclear antigen antibody level ( J:85960 )

• aged mice have higher titers of anti-nuclear antigen IgM

hematopoietic system

decreased mature B cell number ( J:85960 )

• slight, but significant, reduction in mature recirculating B cells in the bone marrow

decreased B-1a cell number ( J:85960 )

• reduction of B-1a cells in the peritoneal cavity, restricted to the CD5+ IgM+ B-1a population

abnormal B cell physiology ( J:85960 )

• in the presence of extracellular calcium, a greater calcium influx is seen in mature B cells than in wild-type, indicating enhanced calcium mobilization

increased B cell proliferation ( J:85960 )

• B2 cells develop normally but mature B cells are hyperproliferative in response to B cell receptor cross-linking or anti-IgM F(ab')2 stimulation

increased IgM level ( J:85960 )

• aged (6-7 months old), but not young, mice have a slight, but significant, increase of serum IgM

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:85960 )

• in the presence of extracellular calcium, a greater calcium influx is seen in mature B cells than in wild-type, indicating enhanced calcium mobilization

cellular

increased B cell proliferation ( J:85960 )

• B2 cells develop normally but mature B cells are hyperproliferative in response to B cell receptor cross-linking or anti-IgM F(ab')2 stimulation