Phenotypes associated with this allele

• Allele Symbol: Pitpnm2^tm1Tili
• Allele Name: targeted mutation 1, Tiansen Li
• Allele ID: MGI:2679326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pitpnm2^tm1Tili/Pitpnm2^tm1Tili	involves: 129 * C57BL/6	MGI:2679327

Genotype
MGI:2679327

hm1

• Allelic Composition: Pitpnm2^tm1Tili/Pitpnm2^tm1Tili
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85900 )

• homozygotes are viable, fertile, and healthy with no apparent growth deficits relative to wild-type mice

• histological and immunocytochemical analysis of mutant retinas and ERG analysis indicated normal rod and cone photoreceptor survival and normal a- and b-waves, with no gross defects in the inner retina up to at least 18 months of age

• immunolabeling with cell-specific markers and ERG analysis revealed no structural or functional abnormalities in inner retinal neurons

• preliminary analysis of the hippocampus revealed normal mossy fiber morphology, with no gross abnormalities in dentate granular cells or cells in the CA3 region