Phenotypes associated with this allele

• Allele Symbol: Thra^tm1Brnt
• Allele Name: targeted mutation 1, Gregory A Brent
• Allele ID: MGI:2679056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thra^tm1Brnt/Thra^tm1Brnt	involves: 129S4/SvJae * C57BL/6	MGI:2679063
ht2	Thra^tm1Brnt/Thra^+	involves: 129S4/SvJae * C57BL/6	MGI:2679065

Genotype
MGI:2679063

hm1

• Allelic Composition: Thra^tm1Brnt/Thra^tm1Brnt
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85803 )

Genotype
MGI:2679065

ht2

• Allelic Composition: Thra^tm1Brnt/Thra⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

adipose tissue

increased total body fat amount ( J:85803 )

• total body adipose tissue in males is 4.4-fold greater than in wild-type

increased epididymal fat pad weight ( J:85803 )

growth/size/body

increased body weight ( J:85803 )

• males show increased body weight after 2-3 months of age, however females are normal in size

homeostasis/metabolism

impaired adaptive thermogenesis ( J:85803 )

• after cold exposure for 8 hours, core temperature of mutants drops significantly more than in wild-type

increased circulating glucose level ( J:85803 )

• glucose level is 26% higher than in wild-type

• after an 18-hour fast, glucose level is 55% higher than in wild-type mice

increased circulating insulin level ( J:85803 )

• increase in plasma insulin levels under fasting conditons

increased circulating leptin level ( J:85803 )

• serum leptin levels are 5-fold greater than in wild-type at 3 months of age

increased circulating thyroid-stimulating hormone level ( J:85803 )

• 3.4 fold increase relative to control

• TSH levels are higher at 3 months of age than at 10 months of age

increased circulating thyroxine level ( J:85803 )

• T4 concentration is slightly elevated at 3 months of age

increased circulating triiodothyronine level ( J:85803 )

• serum T3 concentration is increased 14% at 3 months of age

decreased core body temperature ( J:85803 )

• core temperature of mutants is 0.5 degrees Celcius lower than in wild-type mice

insulin resistance ( J:85803 )

• due to reduced catecholamine-stimulated lipolysis

impaired lipolysis ( J:85803 )

• mutants exhibit reduced sensitivity to catecholamine-stimulated lipolysis

abnormal enzyme/coenzyme activity ( J:85803 )

• alpha-glycerol phosphate dehydrogenase activity in the liver is reduced 30% at 3 months of age and 50% in older mice

behavior/neurological

decreased food intake ( J:85803 )

• consumption of food is 65% of wild-type

cardiovascular system

decreased heart rate ( J:85803 )

• heart rate at 3 months of age is reduced by 14% compared to wild-type mice

renal/urinary system

oliguria ( J:85803 )

• urine production is 37% of wild-type

reproductive system

reduced fertility ( J:85803 )

digestive/alimentary system

abnormal defecation ( J:85803 )

• feces production is 48% of wild-type

integument

delayed hair appearance ( J:85803 )

• mutants frequently show delayed hair growth, with some mice having no body hair for up to 8 weeks of age