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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ifnb1tm1Ttg
targeted mutation 1, Tadatsugu Taniguchi
MGI:2678753
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ifnb1tm1Ttg/Ifnb1tm1Ttg B6.Cg-Ifnb1tm1Ttg MGI:3719722
hm2
 		Ifnb1tm1Ttg/Ifnb1tm1Ttg involves: C57BL/6 MGI:3719786


Genotype
MGI:3719722
hm1
Allelic
Composition		 Ifnb1tm1Ttg/Ifnb1tm1Ttg
Genetic
Background		 B6.Cg-Ifnb1tm1Ttg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm1Ttg mutation (0 available); any Ifnb1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast morphology ( J:76097 )
• osteoclastogenesis is enhanced

immune system
abnormal osteoclast morphology ( J:76097 )
• osteoclastogenesis is enhanced

hematopoietic system
abnormal osteoclast morphology ( J:76097 )
• osteoclastogenesis is enhanced




Genotype
MGI:3719786
hm2
Allelic
Composition		 Ifnb1tm1Ttg/Ifnb1tm1Ttg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnb1tm1Ttg mutation (0 available); any Ifnb1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to infection ( J:116703 )
• murine cytomegalovirus replication in macrophages is increased greater than in Tyk2tm1Shmd homozygotes but not as much as in Ifnar1tm1Agt homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory