Phenotypes associated with this allele

• Allele Symbol: Mtf2^{Gt(U3Betageo)1Ruiz}
• Allele Name: gene trap 1, Patricia Ruiz
• Allele ID: MGI:2678466
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtf2^Gt(U3Betageo)1Ruiz/Mtf2^Gt(U3Betageo)1Ruiz	involves: 129S2/SvPas	MGI:4946502
hm2	Mtf2^Gt(U3Betageo)1Ruiz/Mtf2^Gt(U3Betageo)1Ruiz	involves: 129S2/SvPas * C57BL/6	MGI:2678489

Genotype
MGI:4946502

hm1

• Allelic Composition: Mtf2^{Gt(U3Betageo)1Ruiz}/Mtf2^{Gt(U3Betageo)1Ruiz}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:170279 )

• all mice die before weaning

skeleton

abnormal axial skeleton morphology ( J:170279 )

abnormal sternum morphology ( J:170279 )

• shifted anteriorly

increased rib number ( J:170279 )

• mice exhibit ectopic ribs on the seventh cervical vertebrae unlike wild-type mice

abnormal odontoid process morphology ( J:170279 )

• on the first cervical vertebrae

vertebral transformation ( J:170279 )

• mice exhibit posterior transformation at thoracolumbar and lumbosacral transitions unlike wild-type mice

thoracic vertebral transformation ( J:170279 )

• all mice exhibit T1 to T2 transformation

• all mice exhibit T7 to T8 transformation

• all mice exhibit T13 to L1 transformation

cervical vertebral transformation ( J:170279 )

• all mice exhibit C1 to C2 transformation

• all mice exhibit C2 to C3 transformation

• all mice exhibit C5 to C6 transformation

• all mice exhibit C7 to T1 transformation

lumbar vertebral transformation ( J:170279 )

• all mice exhibit L5 or L6 to S1 transformation

cellular

delayed cellular replicative senescence ( J:170279 )

• in mouse embryonic fibroblasts

Genotype
MGI:2678489

hm2

• Allelic Composition: Mtf2^{Gt(U3Betageo)1Ruiz}/Mtf2^{Gt(U3Betageo)1Ruiz}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

growth/size/body

decreased body size ( J:85162 )