All Phenotypes Itsn1<Gt(pT1ATGBetageo)1Ruiz> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:196062 )

N	• mice exhibit normal hippocampal synaptic transmission and plasticity

decreased brain size ( J:196062 )

abnormal brain white matter morphology ( J:196062 )

• the corpus callosum, ventral hippocampal commissure and anterior commissure exhibit a loss of fiber tracts compared with control mice

abnormal corpus callosum morphology ( J:196062 )

• lack of midline

abnormal anterior commissure morphology ( J:196062 )

• the anterior portion of the anterior commissure lacks a midline

decreased anterior commissure size ( J:196062 )

• greatly reduced posterior portion of the anterior commissure

abnormal hippocampal fimbria morphology ( J:196062 )

• the interhemispheric crossing of the ventral hippocampal commissure is absent at the medial longitudinal fissure

abnormal hippocampal fornix morphology ( J:196062 )

• the interhemispheric crossing of the ventral hippocampal commissure is absent at the medial longitudinal fissure

behavior/neurological

impaired contextual conditioning behavior ( J:196062 )

• mice exhibit less freezing compared with wild-type mice

abnormal spatial learning ( J:196062 )

• in a Morris water maze, mice fail to learn the location of a hidden platform and fail to exhibit a strong spatial bias for the zone where the platform was located unlike wild-type mice

impaired coordination ( J:196062 )

• impaired bimanual motor coordination in a grid test

growth/size/body

decreased body size ( J:196062 )

• at 3 weeks

• however, mice recover weight by 3 months

decreased body weight ( J:196062 )

postnatal growth retardation ( J:196062 )

• some mice fail to thrive

Allelic Composition	Itsn1^{Gt(pT1ATGBetageo)1Ruiz}/Itsn1^{Gt(pT1ATGBetageo)1Ruiz}
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itsn1^{Gt(pT1ATGBetageo)1Ruiz} mutation (0 available); any Itsn1 mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85162 )

Allelic Composition	Itsn1^{Gt(pT1ATGBetageo)1Ruiz}/Itsn1^{Gt(pT1ATGBetageo)1Ruiz} Itsn2^tm1Egan/Itsn2^tm1Egan
Genetic Background	involves: 129S2/SvPas