Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Sieg mutation
(0 available);
any
Bdnf mutation
(41 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Sieg mutation
(0 available);
any
Bdnf mutation
(41 available)
Tg(Camk2a-cre)1Szi mutation
(0 available)
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nervous system
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• significant decrease in the magnitude of LTP induced by 200 Hz tetanic stimulation, such that the mean field EPSP measured 1 hour after induction of LTP is enhanced to only 145% of its pretetanus level in mutants compared to 198% enhancement in controls
• the enhancement of FM 1-43 (a fluorescent marker of synaptic vesicle cycling) release from presynaptic terminals seen in controls during high-frequency (200 Hz) tetanic stimulation is blocked in mutants; rate of FM 1-43 release during low-frequency (50 Hz) tetanic stimulation is normal
• mutants exhibit a smaller magnitude of LTP 1 hour following theta burst stimulation, with an enhancement in the fEPSP to 136.7% of it's initial value compared to 166% in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Sieg mutation
(0 available);
any
Bdnf mutation
(41 available)
Tg(Camk2a-cre)3Szi mutation
(1 available)
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normal phenotype
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• mutants exhibit a normal hippocampus, normal lifespan and no defects in long term potentiation (LTP)
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Analysis Tools