Phenotypes associated with this allele

• Allele Symbol: Ugdh^lzme
• Allele Name: lazy mesoderm
• Allele ID: MGI:2678264
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ugdh^lzme/Ugdh^lzme	C3Fe.B6-Ugdh^lzme	MGI:2678267
hm2	Ugdh^lzme/Ugdh^lzme	involves: C3HeB/FeJ * C57BL/6J	MGI:3580811

Genotype
MGI:2678267

hm1

• Allelic Composition: Ugdh^lzme/Ugdh^lzme
• Genetic Background: C3Fe.B6-Ugdh^lzme

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:85651 )

embryo

abnormal mesoderm development ( J:85651 )

• failure of mesoderm migration results in an accumulation of cells in the amniotic cavity at E7.5

embryonic growth arrest ( J:85651 )

• arrest during gastrulation

embryonic growth retardation ( J:85651 )

• mutants never reach the size of wild-type E8 embryos

abnormal primitive endoderm morphology ( J:85651 )

• endoderm cells fail to migrate correctly and embryos exhibit a thicker endodermal cell layer at the posterior side of the epiblast

abnormal extraembryonic mesoderm development ( J:85651 )

• extraembryonic mesodermal cells fail to migrate normally in embryos

growth/size/body

embryonic growth retardation ( J:85651 )

• mutants never reach the size of wild-type E8 embryos

Genotype
MGI:3580811

hm2

• Allelic Composition: Ugdh^lzme/Ugdh^lzme
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:98216 )

embryo

embryonic growth arrest ( J:98216 )

• arrest at E8.0

abnormal primitive streak morphology ( J:98216 )

• streak bulges into amniotic cavity